HW assignment Day 21
Reading: ReRead section 3.2 to p. 196, including Significance
p. 193. Read Matched pairs and block design pp. 196-8;
review
ch. 3. Next: 4.1, 2, 3. We'll do
4.1,
2, 3. Skip 4.4 and Skip Ch. 5.
Example: Suppose 95% of the
subjects
had their headaches cured by treatment 9 and only 25% by
treatment
1 (placebo). IF the medicine in fact did "no good" that would be
a very unlikely outcome. So we will say the difference in
headache
cures between treatment 1 and treatment 9 is "statistically
significant"
and be inclined to believe the medicine "works".
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= = = = = = = = = = = = = = = = = = =
Fancier Experimental designs (not "completely
randomized")
Control extraneous variability
by pre-sorting individuals into homogeneous groups.
Matched pairs: To compare
Control
and experimental
treatments
(i.e. 2 levels)
Sort experimental units into "matching"
pairs.
One member of pair gets control, other gets experimental.
Randomize which.
Compare within pair,
then
summarize all comparisons.
Common: Do the control and experiment to same
individual (matched with self). (Randomize order)
Are right feet bigger than
left feet? (not an experiment) Sunburn
salve
experiment?
Aside: Sampling data, "longitudinal
study" following same people through time.
Works like matched pair to control variability.
Block design: Sort experimental
units into "Blocks" = groups homogeneous on potentially
confounding
variables
e.g. M/F, age, income, weight, fruitflies
wild or curly-winged. (No randomization here.)
Within each block, randomize the treatments.
Compare
results within each block, then summarize all results.
(Matched pairs is a special case of block
design--each
pair is a "block".)
Exam 2 material ends here.
Questions? Bring more on
Wednesday
Start
here Wednesday, after exam questions.
Not in text: In practice, the
ideal requirements may not be met: Sometimes the treatment cannot
be deliberately imposed and we must observe it (and the
response)
when it happens. (Can't force people to smoke.)
"Prospective study--retrospective study."
--Prospective: You get your subjects before something
(e.g. disease) happens to them, can get information from them.
Then
it happens (or doesn't). E.g. enlist 1000 women, collect info,
wait
5 years. See who gets the disease. An observational study, but More
like an experiment than
--Retrospective: Ask people with/without disease
what they were/are like. (Problems: Reliability of remembered
info,
matching, sampling) (My mother's headaches)
Ch. 4, Probability and Sampling Distributions.
Chance behavior (a random phenomenon):
Unpredictable
in the short run, predictable regular pattern in the long run.
(Random numbers: equally
likely in the long run. "Random" in this chapter is more
general--pattern
is not necessarily equally likely)
25 digits from the random number table: Individual
sets of 25 showed much variability. Pooled shows
more
"flatness" --but still much variability. You would be right to be
skeptical when I told you that your "pick-a-number" choices were not
random,
on the basis of just this class's data.
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We know that a sample from a population will
not exactly represent the population. If we take a random
sample, the behavior of samples will not be individually
predictable, but there will be predictable pattern in many random
samples from the same population. Knowing the pattern will
be
as good as we can do.
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